Do U Want To Live Forever???

[SoulManX]

Longevity Pill Tested in Humans


Sirtris Pharmaceuticals announces that its souped-up version of resveratrol has passed early tests in humans.
What if I told you there was a pill that slows aging and allows you to live a healthy life to age 100?
Such a pill may exist right now. It's being tested in people in very early-stage human clinical trials. Today, the company making the pill, Sirtris Pharmaceuticals (http://www.sirtrispharma.com/), announced its findings from preclinical testing in cells and animals, and also from tests conducted on 85 male volunteers this summer.


The verdict: so far, the pill works, although it will be years before we know how well it works, or if it can actually extend the life span of people in the same way that it has bumped up the life span of mice.


Speaking today at the Annual Metabolic Diseases Drug Discovery and Development World Summit in San Diego, Sirtris's senior director of biology, Jill Milne, announced that the drug, SRT501, reduces glucose and improves insulin sensitivity in animal and in vitro studies of the drug's effect on type 2 diabetes. In people, the drug was tested for dose, safety, tolerability, and pharmacokinetics--that is, how well the drug was absorbed, distributed, metabolized, and removed from the body.


Phase 1b trials are already under way to test safety and pharmacokinetics on patients with type 2 diabetes. Later-phase trials will test to see if the drug actually works in diabetics.


SRT501 is a proprietary chemical developed by Sirtris that's based on the naturally occurring resveratrol that company cofounder David Sinclair of Harvard University has been studying for its effects in extending life span in a number of organisms, including yeast, flies, and mice. Last year, Sinclair created a sensation when he published a paper in Nature detailing how mice on a high-fat diet that were fed large doses of resveratrol were as healthy as mice on a regular diet.


Resveratrol also sharply extended life span, produced positive changes in insulin sensitivity and other diabetes-preventing mechanisms, and increased energy production in cells. The mice were given very high doses of resveratrol--22 milligrams per kilogram of weight. In comparison, a liter of red wine delivers 1.5 to 3 milligrams. To match the results in the mice, a 150-pound human would need to drink 750 to 1,500 bottles of wine a day.


Sinclair says that SRT501 is a thousand times more potent than naturally occurring resveratrol, which gives it the same punch as the resveratrol in all those bottles of wine.


Sinclair believes that resveratrol activates a gene called SIRT-1, which is associated with the regulation of life span in several animals. This contention is disputed by some critics: they argue that the mechanism by which resveratrol works is still poorly understood.


Because humans are so long-lived, SRT501 can't be easily tested for longevity in humans--nor does the Food and Drug Administration recognize "increased life span" as an allowable indication for an approved drug. This is why Sirtris is testing SRT501 for diseases related to aging, such as type 2 diabetes. However, should the drug be approved for diabetes, it will undoubtedly be used to extend life span by many people without diabetes.


The drug still has years of testing to go and faces many hurdles. It may not work. But if it does, the consequences will be profound. For instance, it will mean that more people will be alive on the earth. Age 90 will be the new 70, and 70 the new 50, with profound impacts on everything from social security to retirement age. It may also mean fewer people with diabetes, Alzheimer's, and some cancers.


Can one pill do and cause all that? Critics have long said no--that such a compound will not work in humans. But they also said it wouldn't work in mice--until it did work. (At least in fat mice.)
So let's sip some pinot noir and wait for more results from Sirtris. After all, we're not getting any younger.
Look for my profile of longevity researcher David Sinclair in the September/October issue of Technology Review

[MildSoss]

Foxy grandma, forever!! :woot:

[Obi-Ron]

Doesn't mention any side effects.

[R0rschach]

Who knows this might work and we'll become sterile in the process.
You can't F with nature unless you wish nature to F you up.
Everything has a price.

[LouFerignoDemon]

I thought the thread meant literally live forever from the title (which the answer is no), but a few extra hundred years wouldn't be so bad.

[Deep Thinkin'!]

If it means better health, I wouldn't mind.

But then again, health doesn't bug me. It's the conflicts between humans that bugs me.

[wiegeabo]

I thought the thread meant literally live forever from the title (which the answer is no), but a few extra hundred years wouldn't be so bad.

I agree. But eternity might be nice if you can bring your friends and family along for the ride. Hang out together for a few decades. When you get sick of each other, you move on and explore for a century or two. Then when you all get back together you'll have tons of stories to tell each other for the next few decades.

[LouFerignoDemon]

No possible way would I ever want to live that long, or wish it on another.

[PLAS]

if you can't make it past 60 on your own, you shouldn't be able to live that long

[PLAS]

I remember reading a short sci fi story called "What if it works" and tackles the same issues presented here, instead of a pill it was shot, but the consequences were, you know how sci-fi works

[The Question]

No possible way would I ever want to live that long, or wish it on another.

I don't know. We can make guesses and assumptions as to what reaching such ages would be like, but we wouldn't really know unless we reach them, would we? I've always felt that I should at least try and live forever. Honestly, having a "never say die" aditude is the only thing that keeps me sane these days.

[LouFerignoDemon]

Health and society be damned. I'd not wish it on an entire people or even a few.

[wiegeabo]

The way I'd want it is to stop aging. Then, if I ever get tired of living, for the aging process to start again. Then I could live out the rest of my 'normal' years.

[The Question]

Health and society be damned. I'd not wish it on an entire people or even a few.

Alright.

The way I'd want it is to stop aging. Then, if I ever get tired of living, for the aging process to start again. Then I could live out the rest of my 'normal' years.

Or you could jump of a tall building. That'd be cooler.

[Halcohol]

Doesn't mention any side effects.
Like the fact that you soul passes on when it rightfully should, leaving you to be a decrepit, ancient, unnatural shell of a human being?

[The Question]

Like the fact that you soul passes on when it rightfully should, leaving you to be a decrepit, ancient, unnatural shell of a human being?

That's stupid. You're stupid. :o




Unless, of course, that ends up creating vampires. Then that's cool. And thus, by association, you're cool. I guess.

[LouFerignoDemon]

Van Helsing made me dislike vampires. :o

[The Question]

Van Helsing made me dislike vampires. :o

Van Helsing makes people dislike alot of things. Vampires are still cool. They drink blood and stuff.

[PLAS]

The way I'd want it is to stop aging. Then, if I ever get tired of living, for the aging process to start again. Then I could live out the rest of my 'normal' years.
the cycle of life is much more intricate than what we can actually comprehend, meddling with it is not wise

I'll say it again, want to live a longer, richer life? start becoming a healthier person

[LouFerignoDemon]

Van Helsing makes people dislike alot of things. Vampires are still cool. They drink blood and stuff.


Bleh! :o

[LouFerignoDemon]

the cycle of life is much more intricate than what we can actually comprehend, meddling with it is not wise

I'll say it again, want to live a longer, richer life? start becoming a healthier person

They mean if you could "magically" stop the aging process with zero negative feedback.

[PLAS]

They mean if you could "magically" stop the aging process with zero negative feedback.
and I want my orgasms to last six hours without having to go through hours and hours of yoga before I could actually start practicing tantric techniques

and I also want to have awesome abs without having to sweat in the gym

and I want a hot wife with huge breasts that does my every bidding

oh wait, that's not how it works, does it?

[LouFerignoDemon]

You DO realize this is hypothetical and whimsical, rather than daunting and realistic, oui?

This is a thread about "Do you want to live forever?" Not, "Is it reasonably possible to live forever while having no ill side effects from a chemical induction?"

[Addendum]

No, because the taxes would be a *****

[Super Kal]

good god no... i like knowing that there's an end someday.

[zanos]

This drug would be revolutionary if it really works unfortunately it also endangers the planet at the same time. Can you imagine ppl living longer with the problems of overpopulation right now? Living forever should be reserved for those who have earned the right by chopping off the heads of their fellow immortals.

[Addendum]

Living forever should be reserved for those who have earned the right by chopping off the heads of their fellow immortals.

But then have to deal with ****ty sequels that f*** up the story

[The Question]

But then have to deal with ****ty sequels that f*** up the story

But a pretty decent TV series.

[Mr. Wooden Alligator]

Nope, not through a pill.

[Matt]

Trying to avoid death is ultimately futile. To quote Ian Malcom, "nature will always find a way."

[Mr. Wooden Alligator]

Plus, wouldn't it be lonely when friends and family have gone on?

[wiegeabo]

No, because the taxes would be a *****

But imagine what a couple of centuries of interest would do to your savings account! :hyper:

[wiegeabo]

Plus, wouldn't it be lonely when friends and family have gone on?

Why couldn't they live forever too?

[vertsk8er419]

"I hope I die before I get old!"

[Mr. Wooden Alligator]

Touche

[Kahoot]

pC4ZOxpu2rsTrying to avoid death is ultimately futile. To quote Ian Malcom, "nature will always find a way."
Wasn't he talking about dinosours having babys?

[chaseter]

I would live as long as I could. I want to be an awesome, fit, old man. As for the side effect...I wouldn't mind explosive diarrhea or an urge to gamble or get an erection that lasts for more than 8 hours in order to live to be 120.

[Kritish]

Sure, I'd give it a try.

[Kritish]

good god no... i like knowing that there's an end someday.

If you just get sick of it you can kill yourself, I doubt this drug will combat the effects of a bullet to the head.

[Kritish]

This drug would be revolutionary if it really works unfortunately it also endangers the planet at the same time. Can you imagine ppl living longer with the problems of overpopulation right now? Living forever should be reserved for those who have earned the right by chopping off the heads of their fellow immortals.

Simple, pass a law to where you have to get sterilized to get the drug.

[Untilteld]

No I wouldn't, that'd be lame.

[Kahoot]

If you just get sick of it you can kill yourself, I doubt this drug will combat the effects of a bullet to the head.
For some, killing themself is not an opition. But they could stop taking the pill, one pill can't make you live forever but maybe a pill a day or something.

[Kritish]

For some, killing themself is not an opition. But they could stop taking the pill, one pill can't make you live forever but maybe a pill a day or something.

Wouldn't that be as good as killing yourself? :huh: Suck it up and suck on the shotgun. :up:

[The Question]

Wouldn't that be as good as killing yourself? :huh: Suck it up and suck on the shotgun. :up:

Like I said, jump off a building. There are such pretty colors.

[Kahoot]

Wouldn't that be as good as killing yourself? :huh: Suck it up and suck on the shotgun. :up:
No, have you never seen Bicentennial Man? He let him self die, but that is not the same as killing yourself.

[The Question]

No, have you never seen Bicentennial Man? He let him self die, but that is not the same as killing yourself.

Yeah, but he wasn't trying to kill himself. He was trying to be more human. And anyway, if you want to let yourself die, just don't eat. It's how alot of really depressed old people do it.

[Kritish]

Yeah, but he wasn't trying to kill himself. He was trying to be more human. And anyway, if you want to let yourself die, just don't eat. It's how alot of really depressed old people do it.

Refusing to eat takes a while and it can be painful. I'd rather have instant death like a gun. :up: But if I could have the option a venomous snake wouldn't be too bad. I heard Tai Pan's call kill an adult in a couple of minutes.

[Arcturus]

Yes I would want to live forever.

[Kritish]

Yes I would want to live forever.

Wouldn't it be cool if this is the thing that causes a real life zombie outbreak? :wow:

[Kahoot]

Yeah, but he wasn't trying to kill himself. He was trying to be more human. And anyway, if you want to let yourself die, just don't eat. It's how alot of really depressed old people do it.
At the end he is trying to kill himself coz the UN (or someone) has said that he's a human but he's imortal so he's not a real human. He then makes himself a real human by alowing himself to die.

Also the nurse that the female robot became, she was fine! :wow:

[Arcturus]

Wouldn't it be cool if this is the thing that causes a real life zombie outbreak? :wow:

Yeah! I had that thought going through my head. It would be crazy if scientists were trying to find a way to extend life, but unintentionally find a bring the dead back to life!

Terrifying!

:wow:

[Kritish]

Yeah! I had that thought going through my head. It would be crazy if scientists were trying to find a way to extend life, but unintentionally find a bring the dead back to life!

Terrifying!

:wow:

Some dude who's taken the drug gets hit by a car and dies then he gets back up as a zombie! :wow:

[Kahoot]

Wouldn't it be cool if this is the thing that causes a real life zombie outbreak? :wow:
Why would that be cool?

Zombies = the end of us all!

Zombies are slow bumn f**ker!

[Arcturus]

Some dude who's taken the drug gets hit by a car and dies then he gets back up as a zombie! :wow:
That would be downright creepy!

[Kritish]

Why would that be cool?

Zombies = the end of us all!

Zombies are slow bumn f**ker!

I've always wanted to live in one of those city fortresses like in Land of the Dead. :ninja:

[Untilteld]

Why would that be cool?

Zombies = the end of us all!

Zombies are slow bumn f**ker!

Yeah, but when in life do we get a chance to shoot a zombie in the face? I say bring the zombies.

[Kahoot]

I'd rather be infected by Rage that become a Zombie... But the Rage victums can die when they run out of food, Zombies I'm not too sure about.

[The Question]

Refusing to eat takes a while and it can be painful. I'd rather have instant death like a gun. :up: But if I could have the option a venomous snake wouldn't be too bad. I heard Tai Pan's call kill an adult in a couple of minutes.

Once again. Jump of a building. It's much more impressive.

[Kritish]

Once again. Jump of a building. It's much more impressive.

But I like snakes. :csad:

[The Question]

But I like snakes. :csad:

Yeah, Snakes are good too. I'm just saying, if you're dead set on dying, you should do it with some style. Now, the preferable option is to go all Thermopolae/Roark's Drift and take as many bastards down with you as possible. But those don't happen every day.

[Kritish]

Yeah, Snakes are good too. I'm just saying, if you're dead set on dying, you should do it with some style. Now, the preferable option is to go all Thermopolae/Roark's Drift and take as many bastards down with you as possible. But those don't happen every day.

Going out Virginia Tech style wouldn't be too bad. :o

[AhabTheArab]

nobody wants to live to 100... except the guy who's 99....

[Kahoot]

nobody wants to live to 100... except the guy who's 99....
I'm betting most of them wouldn't mind dieing, they'll be alone, there partner will likely be dead. And most will be trapped in an old folks home.

[The Question]

I'm betting most of them wouldn't mind dieing, they'll be alone, there partner will likely be dead. And most will be trapped in an old folks home.

I really don't think it's safe to make assumptions like that. Not everyone wants to throw in the towel because things are bad.

[Kahoot]

I really don't think it's safe to make assumptions like that. Not everyone wants to throw in the towel because things are bad.
I'm not saying they are gonna jump from a building, I'm saying they probably wouldn't mind dieing. There is a differece.

[The Question]

I'm not saying they are gonna jump from a building, I'm saying they probably wouldn't mind dieing. There is a differece.

And I'm saying it's not safe to assume something like that. You say that to the wrong person, they'd probably find it deeply insulting.

[ang_hulk]

who wants to live forever!?!?!?! who dares to know forever!?!?!?!?!

[Warhammer]

I don't want to be like Vandal Savage. :csad:

[Lighthouse]

I want them to fix my kidney failure first, then I'll worry about living forever.

[Lighthouse]

who wants to live forever!?!?!?! who dares to know forever!?!?!?!?!

I am immortal!! I have inside me blood of kings, yeah!!

[redmarvel]

Longevity Pill Tested in Humans


Sirtris Pharmaceuticals announces that its souped-up version of resveratrol has passed early tests in humans.
What if I told you there was a pill that slows aging and allows you to live a healthy life to age 100?
Such a pill may exist right now. It's being tested in people in very early-stage human clinical trials. Today, the company making the pill, Sirtris Pharmaceuticals (http://www.sirtrispharma.com/), announced its findings from preclinical testing in cells and animals, and also from tests conducted on 85 male volunteers this summer.

Look for my profile of longevity researcher David Sinclair in the September/October issue of Technology Review

Why only male volunteers... what happens to the females? :wow:

[SoulManX]

Why only male volunteers... what happens to the females? :wow:

Red Marvel: The Last Women On Earth.

With millions of horny men:ninja:

[LouFerignoDemon]

Plus, wouldn't it be lonely when friends and family have gone on?

Most likely, the drug would work on them too.

[Ahura Mazda]

If this actually works the pharmaceutical company that owns it is going to make a fortune...this is a real gold mine. And I am pretty sure almost everyone will end up taking it.

[redmarvel]

Red Marvel: The Last Women On Earth.

With millions of horny men:ninja:

:woot: Party Time BlackHarKnight ;)

[Kahoot]

Isn't the world over populated enough? Do we really need millions of people who are going to life forever?

[LouFerignoDemon]

The reason for childbirth would probably dissapear or near it, creating a slow slow slow incline of population, probably allowing for more death through violence and crime.

[Vilya]

But 100 years isn't forever right ?? call me, when they found immortality pill :D