Re: Black Widow or Madame Masque???
^I'd say both Marvel and DC. The last decent female villain we had that wasn't portrayed in a somewhat simpathetic light was Ursa in Superman 2. Mystique was part of the evil mutants(who were simpathetic since they were fighting against their own oppression) and Catwoman was more of an anti-hero.
Most anticipated TV shows of Fall 2015: Jessica Jones Season 1, Agents of Shield Season 3, Flash Season 2, iZombie Season 2, Blind Spot Season 1, Arrow Season 4, Supergirl Season 1