I talked with Mike Mignola at the SDCC. While I was there, he was talking to a few other industry folks and one brought up this exact quote. He absolutely blew off even a notion that there is any talks of a HB3.
I am paraphrasing here but he said something to the effect of “Yeah Hellboy 3 would be great, just like the 25 other projects Del Toro is attached to.” He actually had a bit of venom behind his words.
It did not sound like a HB3 was even on the radar.