I think Nolan is much more mindful of the source-material than that. If anything, him choosing The Joker had more to do with that damned clown being "The Greatest" of them all, not necessarily the culmination of them all.
I mean, this is the same guy who's used... Scarecrow, Ra's Al Ghul, Henri Ducard, The Roman Falcone, Maroni, Zsaz, Two-Face, and Catwoman before moving onto Bane.
I loved that last interview where Nolan was talking about these villains having some sort of "archetype". It made me glad and sad at the same time -- on one hand with Bane we have someone who doesn't fall into the same ground as any other bad-guy from the gallery, but on the other... because
he mentions archetypes... I just want
to see his interpretations of every one else. But that's pushing it.
I'm glad we see Selina Kyle though. You can't have a Batman trilogy without mentioning Catwoman!