no it doesnt.. there's hundereds of shows that do just fine without supers..
the main cast wouldn't be supers... but... their would most certainly be heroes and villains who show up. And maybe a few characters get powers.... like Jessica Jones
Yeah, but those shows are not produced by Marvel Studios. I just feel if Marvel does a show and it doesn't feature superheroes as part of the main cast then it is big missed opportunity. Smallville and Heroes were fine for what they were, but I largely came away wanting more.