Well, if the Red Skull truly isn't coming back then they might rework Crossbones as something of a fanatical successor. That, of course, would likely draw comparison's to Nolan's version of Bane taking over for Ra's (and it wouldn't help that the two characters look very similar). But that could be the direction they're headed.
Also, check out the trailer to Lay the Favorite. Grillo is in it briefly, and he's already looks JACKED.
Bootleg Batman Begins
: "Bruce found a basement under his villa, in which the equipments turn him into another person: Spiderman. With this mask, Spiderman stroke all criminal activates and criminals everywhere, such as Tougon, the chief of Mafia, Doctor Jackstraw, the abnormal drug trafficker, even a mysterious opponent familiar with him