Originally Posted by PancakeFlipper
I can't really see any of the big 4 being killed (Cap, Thor, Iron Man, Hulk).
Samuel Jackson is 63. He might have a a million picture deal but he's not going to be around forever. I could see him being killed off and paving the way for Director Stark. But not likely.
I recall there being rumors of Hawkeye and Black Widow being in Captain America 2, and that there might be a romance between them. If that were true, it could lead to a classic Whedon move: take characters with long standing romantic tension, have them get together, and then promptly kill one of them.
What you've said is actually pretty plausible, aside from the Director Stark thing. It would 100% be Maria who would take over after Nick Fury's inevitable death.