Re: If the Lizard was the villain in Sam Raimi's Spider-Man 4...
By all accounts, it would have been the Vulture. However, to answer your question, I suppose something would have to push Curt into wanting to research regeneration. Then Curt would have to work alongside some researchers/corporation that would fund the research.
"I defeated your uncle Victarion and his Iron Fleet off Fair Isle, the first time your father crowned himself. I held Storm's End against the power of the Reach for a year, and took Dragonstone from the Targaryens. I smashed Mance Rayder at the Wall, though he had twenty times my numbers. Tell me, turncloak, what battles has the Bastard of Bolton ever won that I should fear him?" - Stannis Baratheon