There is probably a good chance that SLJ will appear since he has said he's eager to do so in several recent interviews. Whether or not he does will come down to whether they can swing it in the budget and Whedon's overall plan for the show, I suppose. After Fury's appearances in several of the solo films and The Avengers, it would be strange if he did not show up in his organization's TV show.
My takeaway from the Smulders interview is confirmation of what many of us had suspected, that Marvel will attempt to use these characters between TV and film when and where it makes sense. We may not hear about it, but I think a lot casting for roles in the MCU will have provisions for appearances on TV should SHIELD get picked up, which it most likely will.