Re: Madame Hydra in the MCU...
Yeah, I think Marvel can use the version Ophelia/Madame Hydra, while Fox can use the Viper alias.
Madame Hydra(MCU) will probably be dressed in green, and also have the black hair and green lipstick. Notice how Fox's Viper doesn't have those features, aside from just being dressed in green. Also, Viper won't be connected to HYDRA in The Wolverine, while Madame Hydra will almost definitely be connected to HYDRA.
2015: Avengers: Age of Ultron, Star Wars: Episode VII, Ant-Man, Daredevil, AKA Jessica Jones
2016: Captain America: Civil War, Batman v Superman: Dawn of Justice, Suicide Squad, Doctor Strange, X-Men: Apocalypse, Luke Cage, Iron Fist, Deadpool, Gareth Edwards' Star Wars, Warcraft