Originally Posted by cherokeesam
The evidence shows that they're primarily interested in creating brand new characters on both the hero and villain side.
There is no evidence of that in the slightest.
The main agents of SHIELD are made up, yes, and for good reason. Joss can now do whatever he wants with each character, which is great for an ongoing tv series.
But beyond those characters there's no evidence of anything. There has been absolutely zero mention of any villains or heroes and there's also been no plot details. All we have to go by is the synopsis and our own imaginations, and I fully expect to see some familiar superheroes and villains, though not in droves like you seem to want.