Originally Posted by JB-the-Hunter
There is no evidence of that in the slightest.
The main agents of SHIELD are made up, yes, and for good reason. Joss can now do whatever he wants with each character, which is great for an ongoing tv series.
But beyond those characters there's no evidence of anything. There has been absolutely zero mention of any villains or heroes and there's also been no plot details. All we have to go by is the synopsis and our own imaginations, and I fully expect to see some familiar superheroes and villains, though not in droves like you seem to want.
Except for, you know, all the evidence that *is* there.
The *only* characters we've been told about except one are invented for the series. And the sole exception to that is a character who was invented for the *movies.* Well, maybe Jasper Sitwell gets a pass, assuming the rumors about him joining the show are true.
Until we get word of any "familiar superheroes and villains" as guest stars or new cast members, the show is almost entirely new characters. I'll be glad for you to prove me wrong someday, but for now, Jasper Sitwell is the only one you can score any points for.