Originally Posted by cherokeesam
And I'll repeat what I posted just before Thread Manager dropped tha bass:
That would make sense if they were talking about Loki, and him being the only one with experience with this person/entity could very well refer to: Thanos and/or The Other. As far as we know, Loki is the only one who's had any experience with the Mad Titan.
There is no allusion to Thanos in any of that trailer though. You're speculating again on a whole other realm of the plot you've previously theorized.