While sexuality is fluid, for some people (thanks to something called the Kinsey scale) it's a bit more "set." If you've never seen her photographed on any kind of romantic date with a man in all of these years, I highly doubt she'd starting experimenting in middle-age.
She is very pretty though. And looks amazing at 50-whatever.
What if she played a gender-flipped Lex? They already gave us a female Jimmy Olsen.