We really need some concrete news on what's going on with this franchise.
I figured I might as well throw my cast out there.
Reed Richards/Mr Fantastic-Paul Rudd (I'm aware he's rumored for Ant-Man butt I think he could be a very solid Reed as well)
Sue Storm/Invisible Woman-Claire Danes (Talented and beautiful I could see her as a great Sue)
Johnny Storm/Human Torch-Josh Hutcherson (He has that Teen idol thing going that I feel would work great for Johnny)
Ben Grimm/The Thing-David Boreanaz (as the football star, who protected his uber intelligent buddy Reed from bullies, and I could just see hear him saying it's clobberin' time!)
Not sure who I want for Alicia or Doom yet.
As for the story I'd like to see Reed discover the N Zone, and have Annihilus as the threat. He'd be cgi and currently not sure who I'd want to voice him.