Re: Ruffahulk Ruffasmash
Madman as I recall has a least some shapeshifting ability. Sort of what Ironclad has going on with density manipulation, but also the ability to grow or shrink.
As for the U-Foes, they may have to be heavily adapted for movie use. Honestly, I don't see them even going down the emulation of Fantastic Four path. Is Simon still power hungry? Of course, why not. But they might as well substitute cosmic rays with gamma mutations. Maybe they're mercenaries hired and experimented on by the Leader? Maybe Simon becomes a business partner of sorts to Leader and negotiates for some of that sweet sweet product for him and his associates?
But yeah, since there's so little on their actual personalities, I'd be all for a serious revamp of their origin.