Not sure I'd want to see Supergirl in a new Superman movies - and her being a female knockoff of a popular male comic book hero (a la She-Hulk or Spider-Girl), I don't think she'd be able to support a movie of her own, even without an over-the-top Faye Dunaway, a wasted Peter O'Toole and an unnecessary cameo by whoever's playing Jimmy Olsen.
Now Power Girl, on the other hand...