The QB's who succeed the most in the NFL are the ones who don't win the Heisman Trophy. Cam Newton was the last Heisman Trophy winning QB to have success in the NFL and before that it was Carson Palmer. 16 QB's have won the trophy since 2000 and the jury is still out on Jackson and Mayfield and Mariota has been okay but outside of Newton and Palmer, the rest have done nothing in the NFL. Brady, Brees, Rivers, Prescott, Mahomes, Manning, Roethlisberger, Rodgers, Goff and Foles have never won the Heisman Trophy and all have had NFL success with Brady, Brees, Rivers, Rodgers and Roethlisberger (and maybe Manning) all first ballot Hall of Famers.