I'd rather just outline possibilities as explained above but I'll play the game and mention the following:
July 22, 2022 - Deadpool movie Guest Starring another Marvel character. I'd guess Spider-Man but that rumor of him being in the Captain Marvel sequel seems to be gaining traction for now. The Pg-13 route Disney will take and including a character from another Marvel movie (maybe even Hulk to replace the Hulk vs. Wolverine guest starring Alpha Flight option) will segue around bad PR just as much as letting time pass before an announcement on this comes will as well.
May 2022: Black Panther 2. Doom replacing Sub-Mariner at least for now. (May save sub-mariner for eternals and or inhumans I.P or Fantastic Four IP further down the line instead). Also Black Knight I'm guessing could appear following his appearance in Eternals if he doesn't in Ant-Man 3.
October 7th, 2022, - Blade guest starring 1 or 2 other headline characters. This will be an attempt to attract people to a PG-13 rendition as well.
February 17th, 2023, - Captain Marvel 2 guest starring Spider-Man (presumably continuing off of Spider-Man 3 in some way). This will finish some cosmic crossover storyline in a nutshell (presumably Secret Invasion or Kree vs. Skrull war storyline) giving room for a Nova movie much later that will focus on Annihilation (assuming if Sony and Marvel can't work out another agreement). Post-Credit scene with Earth based villain (presumably Doom instead of Norman but could be General Ross too) making contact with cosmic based one.
May 5th, 2023, - FF (presumably introduced in post-credit scene of Ant-Man 3). The story arc will presumably be the entirety of their lives. If time displaced in the Quantum Realm/Negative Zone expect villains like Annihilus along with earth based ones as well to be introduced.
July 28th, 2023, - Guardians 3 will presumably feature the High Evolutionary supposedly trying to mimic the Celestials as touched upon in Eternals.
November 3rd, 2023 - Thunderbolts/Dark Avengers Like Movie as set-up in Black Widow. The IP's will be meshed together and provide a battle with earth based Marvel characters. (If Hulk and Wolverine team-up guest starring Alpha Flight hasn't happened yet then this will be shoe-horned in somehow within the film providing maybe some hero characters for the Thunderbolts/Dark Avengers to face off against). The film will probably end centering on an even bigger cosmic threat everyone must band together against (perhaps the FF helps make the peace by bringing this to everyone's attention).
Future?: *There will be some huge big event film following causing a huge cosmic shakeup (X-Men introduced here in smaller role to provide added buzz for this film but not the main focal point of story).
Further Future?: The X-Men (as perhaps previously touched upon in Eternals and Dr. Strange 2 by this point) will have a film on them explaining how Deadpool's motley crew not the only ones after the cosmic shakeup somehow.
Another smaller yet still big event perhaps touching on Annihilation will follow as well perhaps another repercussion from the events of the huge shakeup film or maybe instead just be a continuation of a smaller story stemming off from Captain Marvel 2.