I can't see Mysterio making an appearence because he has no physical threat towards Spidey, he doesn't allow for big fight scenes.
That's interesting, I never really thought of that
t:
But he can create illusions... so the options are wide open to get a beautiful action scene
Ok, so... The Lizard, Electro, Kraven, Scorpion, Rhino, Vulture, Carnage, Mysterio, Chameleon...
-Lizard seems like the obvious choice, so I think it could be on it.
-I don't want to see Kraven.
-I would like to see what they do with Electro and that horrible thunder-mask
-The tail of the Scorpion could become too similar to the Doc Ock's tentacles.
-Rhino is not that believable villain as the rest, BUT on the other hand, it could be great for action scenes.
-Vulture... the old man flying with a green fur suit? No way
-Carnage... another
possible choice. But to get it fit with Spidey 3, Cletus Kassady should appear/be named somehow in Spidey 3.
-Mysterio... I already said so.
-Chameleon.. it could get kinda M:I II with the fake identities. It has been used
I say: Lizard main villain, Rhino appearance (like New Goblin), and Electro (if they do it correctly)
D!