I would be fine with more X-movies, but enough of making them focus on Wolvie- his arc, like most of the older X-Men, is complete. Iceman has gotten better and better development each film, but not a full arc yet, and neither has Pyro (his has been started but needs to be finished). Kitty could have cool development and has unique enough powers where some cool symbolic stuff could be set-up, maybe something where she won't let anyone close to her and its reflected with her powers (the actual Bobby/Rogue/Kitty love triangle, maybe?). Colossus, thematically, is pretty much the equivalent of Logan, being invulnerable to others even if you don't want to be- he has tons of potential.
As for the original post saying no sentinels, sinister, apocalypse, and so on, I agree to some extent. I think it would be cool to see realistic sentinels (not the giant one like the danger room), and I would absolutely love to see Pyro be in control of his own super-violent Brotherhood- it would be cool to see mutants being very violent just for the sake of hurting as many humans as possible, plus Pyro for that film could be set-up as a tragic victim whose a victim of society, and get killed off in the end.
I think as long as its done realistically and with a serious tone, X4, and the rest after that, could be a good film- they just can't go overboard on trying to translate a lot of comic material to the big screen, because a lot of it just won't translate.