1. "Sex and the City" - a somewhat well-written show, but the main characters were incredibly annoying people I could never feel sorry for when bad things happened to them.
2. "Penny Arcade" - I've made no secret of my distaste for this webcomic. I can understand why gamers might like some of the industry references, but the humor is strictly wannabe Kevin Smith-type stuff that usually relies on the word "f**k" as a substitute for an actual punchline. And speaking of Kevin Smith...
3. Any Kevin Smith movies after "Chasing Amy" - Maybe it's because all the geek-chic ironic humor of the mid 1990s has been done to death by this point, or maybe it's because I'm not 20 years old anymore, but Kevin Smith just bores me. I liked the unpredictible low-budget weirdness of "Clerks" and the unexpected comic book shout-outs in "Mallrats", but about halfway through "Chasing Amy", I realized I wasn't having as much fun anymore because Smith was taking his "message" way too seriously for such a film. The pretentious college-freshman-philosophy-major soapboxing got worse with "Dogma", and then I just stopped caring all together.
4. Will Ferell's unscripted improv humor. I loved "Elf", I hated "Anchorman" - that pretty much sums it up.
5. About 50% of "Robot Chicken" could be a lot funnier that it is. The ideas are usually good, but somewhere along the line, Seth Green just decides to fall back on no-brainer jokes like bestiality or a character yelling "*****ebag!" It's too bad, because other skits on the show are hilarious.
6. "Family Guy" -- Summed up best on "South Park" -- just one random, interchangable joke after another.