Let's talk love interests/leading ladies.

My favorites:
Lois Lane (Margot Kidder)
Karen Jensen
Vicki Vale
Mary Jane Watson-though she was a bit helpless, I liked the relationship between Peter and MJ and it developed, especially over the course of the first movie.
Selina Kyle (both Michelle Pfieffer and Anne Hathaway)
Jean Grey-not sure if she is really a love interest but she's on my list.
Roxanne Simpson-Eva Mendes was one of the few things about Ghost Rider that I really liked. I also liked the actress that played the younger Roxanne.
Nyssa Damaskinos
Gwen Stacy (Emma Stone)
Peggy Carter
Betsy Ross (both Jennifer Connelly and Liv Tyler)
Lana Lang

Worst:
Lois Lane (Kate Bosworth)-completely miscast. Drab and uninteresting.
Jane Foster-(Sorry, but despite me liking Natalie Portman as an actress, I thought the character and actress were wasted, the relationship building was rushed)
Chase Meridian
Abigail Whistler (not sure if she was intended to truly be a love interest for Hannibal King or not, just wanted to hate on the movie)
Gwen Stacy (Bryce Dallas Howard)
Rachel Dawes (Katie Holmes)-I actually thought Maggie G. was okay.

 

Kirsten Dunst as MJ is my least favorite. We had to endure her for three movies. She was a horrid selfish girl.

 

Not counting Catwoman, who isn't really a traditional love interest in her many iterations, my favorite is Gwyneth Paltrow's Pepper Potts. Her spats with Robert Downey Jr are a highlight of the Iron Man films. They have fantastic chemistry. She's the second best character in those movies, which is really quite an achievement.

Worst is the Katie Holmes version of Rachel Dawes who is the clear weakpoint in an otherwise great film.

 

I'm sorry for "bumping" this thread, but I just wanted to voice my opinion about Gwen Stacy. How the HELL is she one of the worst love interests? She, IMO, is one of the best. She is intelligent, she helps Peter when he's Spider-Man, takes part in defeating the main bad guy, and is a very strong character. Her and Garfield had great chemistry, and Emma Stone's performance is great. There were issues with The Amazing Spider-Man, but Emma Stone's Gwen Stacy was definately NOT one of them.

 

Pepper is my favorite as well. Kidder was good as Lois in 2 films, Atwell was awesome as Peggy Carter, Emma Stone was great as Gwen Stacy, Portman as good as Jane Foster as was Liv Tyler as Betty Ross. Hathaway as Selina Kyle was the best thing about TDKR. And Connelly was wonderful as Jenny Blake. Not sure if I can think of any more I liked. Oh, Wright was pretty good as Karen Jensen. That's about it. I treat love interests who also happen to be superheroes in their own right as a separate category, so no Natasha Romanov, Jean Grey or Rogue on this list.