I preferred Byrne's version of her in Fantastic Four, or in her graphic novel. She had enough sass and fun, but wasn't overboard and still normal. When he began writing and illustrating Sensational She-Hulk, it just because frivolous fluff with no substance at all and completely wacky. It was like reading Howard the Duck or watching either the Ultimate Spider-Man cartoon or that show Limitless (which was almost like a live action version of the Ultimate Spider-Man cartoon).
I don't mind some forays into fantasy like Ally McBeal, because that even had its serious moments, but not a complete lack of substance all the time and being silly for the sake of silliness. When it gets like that, the character (whichever comic or show it is) ceases to be a real person but just a complete caricature where you see that no-one would ever act like that in real life.