In case someone misses it...
I'm not suggesting they're comparable.. the devil is obviously more evil than Venom ever was...
BUT... the point I was trying to make is that when everybody was going on about how irresponsible it was for Peter to make such a deal with Satan, we have precedents of Peter making similar irresponsible deals with other bad guys in the past.
Just because Peter has the "with great power comes great responsibility" motto doesn't mean that he has always taken the responsible road... and his deals with Venom are one of many.
I have to give you credit, TMoB. You've been very careful to avoid discussing the particulars of any "deals" made so far, which in my view is the other important thing to consider. Also, as someone who likes the X-Men (though not Wolverine) I can tell you that Logan has probably killed/maimed more innocents than even Venom, but since he is Marvel's other cash cow everyone gives him a pass for it.
I can think of two instances where the two came to a sort of "deal," but feel free to add more if I'm missing any. There was the time Venom agreed to stop trying to kill Spider-Man (I believe it was after they had just worked together to save Brock's ex-wife from a fallen ferris wheel and Venom realized killing Spider-Man would kill all the innocents he would save, too). However, Peter didn't just give Eddie a free pass and tell him he could go kill all the people he wanted for letting him live a Venom-free life.
The second time I can think of off the top of my head was during "Maximum Carnage," and in that situation the immediate threat was posed by Carnage and his roving band of killers. Peter knew he needed help to stop them, and it would have been stupid of him to turn down Venom's help since apparently every other superhero team (except Cap from the Avengers!

) was out of town. Oh, and Firestar was hanging around, too. Anyway, this was a case of Peter choosing the lesser of two evils (though Venom wasn't even really "evil" at the time; he was in his "Lethal Protector" phase). Carnage was slaughtering hundreds, Venom wasn't. That's a rather simple choice. It's not even a choice, really. Either accept help from your former enemy and stop the murderers or fail and watch people die, probably dieing yourself.
Now, look at the choice in OMD. This is a totally different situation. While the earlier "deals" were about protecting others and stopping evil (with Carnage), in this case the deal is about giving the evil guy (the ultimate evil guy) a victory over god. While the other deals were selfless acts, with Peter putting his life on the line, this one was purely selfish. We were shown time and again how Peter moaned about not being able to stand May's death, how he couldn't be responsible for her passing. As has been stated before, May and MJ took on the responsibility when they convinced him to unmask. May unburdened Peter of any decision when she specifically told him that she was ready to move on - she actually WANTED to be let go, to be with her husband. Yes, it would have been painful, but at that point Peter should have lost any last, lingering shreds of responsibility for her situation - it was time for May to pass on.
Instead, Peter basically guilts MJ into making the deal for him before accepting it himself. Remember, she was very much against it in the beginning and even lashed out at him verbally for basically saying he would blame her if they let May die. That's why the deal was accepted. So, we have selfless acts where Peter risks his life to protect others against a deal with ultimate evil where Peter trades off his wife and their happiness so that his aunt can live and he doesn't have to feel guilty, despite her wishes, her commands, to the contrary. I just don't think you can even begin to compare those situations, and if you do it certainly doesn't come out favorably for your arguments.