I feel as though they have a clean slate to plant the Sinister 6 seed. The Avengers will also be venturing into space, perfect time to have the symbiotie latch onto something or Spidey and make its way back to earth. I really want to see Tom get his butt kicked by the 6, and then destroy them while one with the symbiotie. Show a deadly Spider-Man, a ruthless Spider-Man. Ultimately this would lead to a movie with Venom as the main villain. I know there's a ton of people on here who don't care for Venom, and I definitely see the "all visuals, no substance" arguments that are brought up. However, I do believe he sells and with Marvel they'll find a way to make it work.