I'm wondering if the symbiote will be in there healing Harry, meant to feed on his disease, but feeds on much more, Harry's face & body disfigured, goblin like, it makes him crazy & strong, he then breaks out as Peter sneaks in based on MJ's intel, but somehow maybe in a fight, the symbiote attaches to Peter. Peter goes to sleep exhausted, gtav-like drunk dream sequence

funny

wakes up with black-suit.
At the end, during their fight, Suit slightly takes over & Pete gets carried away and "kills" Harry. Pete distraught over "killing" his friend, desperately tries to rid of suit, learns of its sensitivity to high frequencies from the fight vs Harry Goblin (vs Harry's weapons maybe). Eddie Brock who has been stalking them for the Bugle this whole time, ends up being next host. (Not sure about revenge motive) Playable Eddie Brock perspective with Spider-Man vs Harry Goblin going on in the background.
Ending set up to next game, Norman vengeful vs Spidey for killing his son, injects himself, puts on the suit based on the prototypes we saw in 1st game, knowing the injection will difigure then eventually kill him, but wants to kill Spider-man before he himself dies. Maybe.