1) I would love to see a Blade MAX series, patterened something along the lines of the Ennis series or Aaron's PunisherMAX. With Blade being based more on the movie version and universe, with some things from the comic Blade thrown in there and reimagined. I also would perhaps team him with his vamp girlfriend from the MI:13 series, a way to acknowledge that part of his backstory. But other than that, I would keep interactions with costumed superheroes out of the book, or at a bare minimum.
2) Get more promotion for Black Panther and the Doomwar storyline, revamp his villains and then farm them out to the rest of the Marvel U so they can get some notoriety, and also take some major and minor villains in the Marvel U and have them go against Panther more. There's a lot of underused villains that might go well with Panther.
3) This is a Marvel board, but about DC, I would've loved to see them do a Dark Reign type storyline when Lex Luthor had been president. It would've made for some potentially great stories that could logically be extended, unlike the Blackest Night storyline IMO.
4) Another DC, I wish they had done a "Dark" Batman and Robin (Jason Todd and Damien) for the new Dynamic Duo. I think that would be neat.
5) A War Machine miniseries to coincide with Iron Man 2.