Go buy some instant pizza dough mix and roll out a rectangular piece that is big enough to completely cover your baking dish on the inside and on the sides. The crust should slightly come out over the dish. I use a silicone deep dish which makes it easy to remove. Be sure to properly flour the crust. Put it into about a 350 degree oven just to allow the crust to start to cook a little bit before you add in the wet ingredients. You can make the crust thin or thick, your choice.
Cook some lean hamburger meat with salt, pepper, and garlic. Drain the grease from the meat completely. Your crust should be done by now.
Cook your penne pasta and leave it a little al dente because it is going to be cooked again. Drain the pasta.
Combine the pasta and meat with your favorite pasta sauce. Add everything to the crust.
Cover completely with fresh and grated mozzarella cheese. Add pepperonis to the top. Don't completely cover it...make it look like a pizza. Cook for about 15-30 minutes or until the cheese has began to lightly brown or become golden. The crust should be also be golden and crispy.
Cut and serve...mmm delicious.