When all is said and done,which villain(or villains)do you think made the biggest impact on Peter,emotionally? Now,I'm not talking about which villain gave the best performance or who was more evil,but when Peter looks back on his life as Spider-man,which baddie do you think he'll remember most? I might have to say Green Goblin would probably be the one to haunt Peter for the rest of his life. I wouldn't even say the Goblin himself,but maybe his legacy. The Goblin was his first major foe and turned out to be his best friend's father. And even once the Goblin was killed,Peter still had the guilt of what happened and the pain of seeing his best friend deal with Norman's death. And even when he thought he was out of the woods,Harry become the New Goblin and attacks him. The memory of the Goblin pretty much haunted Peter over the course of the trilogy. In a way you could say Sandman too,because of him "killing" Uncle Ben. Although I would think that Peter would miss his Uncle more than hating Marko,since Marko revealed Ben's death was an accident and Peter forgave him. I may throw Venom in there too. Despite the lack of screentime and interaction with Spider-man,Venom was the only villain to kill someone that Peter loved and cared for. Even though it was a case of self-scarifice for Harry,I would imagine that Peter would never forget Venom killing his best friend.Plus,that whole saga with the symbiote and what it made Peter do,and how it almost turned him into a monster is something that may cause a few nightmares for him.