DC
Wonder Woman
Create a likeable but not quite transcendent Diana and put her in a fish out of water surrounded by mundanes like Etta Candy, Steve Trevor, Julia Kapetalis, Cassandra Sandsmark, General Phil Darnell, Tom Tresser, Tre Barnes and Veronica Cale. Then introduce a recurring/supporting cast of Themyscirans that support her mission to man's world as the mundane cast help her acclimate to it, and provide the drama and character developments. Start with a greek monster freak of the week for the first season as Ares is the main villain, then the next season introduce more of her comics villains.
Go with the new dark-pants costume, though she has star spangled panties under it. I'd even go so far as to make her hit land amnesiatic so as to introduce both her man's world life as well as her themysciran heritage in pieces instead of trying to cram both into a one hour pilot.
Get a fight choreographer and a stunt-ready athletic actress and have her do a couple months prep (like for a movie) for the basic fight movements needed. Keep the FX relatively light, more Buffy than Heroes, and allow the weight of the characters and their relationships to carry the show. This is why a likeable Diana is key, one that makes girls want to be her and guys want to be with her just when she's talking. See Marston's Diana for a demonstration.
If Rookie Blue didn't work out, someone like Missy Peregrym would be good, since we don't have the movie budget for Anne Hathaway or what have you. That chick from the Seeker could screen test too.
Flash
We basically are doing a CSI: Miami / Burn Notice, with Flash Facts substituting for Ask a Spy and a zoom in on the ring substituting for Horatio putting on his glasses. Barry would be the center, and Wally would be a youngster, getting his powers during the Season 1 finale. A single super-tech corporation would act as the backdrop for how all these incredible devices became so popular (mirror master? Weather wizard? yeah). More basic villains (Cpt Cold, Heat Wave, Boomerang, Trickster) would be the bread and butter of the first season though.
Supporting cast would include Iris, the fiance, the police department characters, Wally, and Barry's neighbors. Casting would skew slightly older, Jensen Ackles might be the way to go, or someone similar.
Marvel
Runaways
Get someone who can write that kind of action-comedy that's needed. Joss Whedon might be a good showrunner, for instance (even if his arc was weak in the comics). Cast typical non-high school high schoolers for most with a real high schooler for Gert and a real child for Molly and run the stories, add in a few more filler misadventures, make sure there's a cool fight scene in each episode, kill off a character each season. Diverge from the comics enough to make people doubt the twists. Grow the characters more organically than was done in the comics. Bring in the viciousness of something like pretty little liars, the shamelessness of something like Secret Life of the American Teenager and the special effects of Heroes. Keep the one liners coming, give the audience an entrance into the world and have a blast. Three part pilot to introduce all of them and their powers. The key would be capturing the franticness an the psychological trauma the kids are undergoing.
Ultimate Spider-Man
Like Smallville, but with a bigger budget and better fight scenes. And more girls. And you don't have to make up the rich-best-friend's-evil-dad character. He's already there in comics.
