General Vulcun
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I found this over at BOF, from a user who got it off IMDB, with a way where Joker's toxin can be made realistic. Check this out:
Excerpt from Clinical Microbiology made Ridiculously Simple (Gladwin and Trattler):
Clostridium tetani causes tetanus, a disease that classically follows a puncture wound by a rusty nail but can follow skin trauma by any object contaminated with spores. C. tetani spores which are commonly found in soil and animal feces are deposited in the wound and can germinate as long as there is a localized environment.
Tetany occurs after the tetanus toxin is taken up at the neuromuscular junction (end plate) and is transported to the central nervous system. There the toxin acts on the inhibitory Renshaw cell interneurons, preventing the release of GABA and glycine, which are inhibitory neurotransmitters. The inhibition of the inhibitory interneurons allows motor neurons to send a high frequency of impulses to muscle cells, which results in a sustained tetanic contraction.
Clinically, the patient with tetanus presents with severe muscle spasms, especially in the muscles of the jaw (called trismus, or lockjaw). The affected patient exhibits a grotesque grinning expression, called risus sardonicus, which is due to spasm of the facial muscles. Mortality is high once the stage of the lockjaw has been reached.
And here's a pic of a guy with the disease:
caep.ca/CMS/images/cjem/p48fig1.jpg
Excerpt from Clinical Microbiology made Ridiculously Simple (Gladwin and Trattler):
Clostridium tetani causes tetanus, a disease that classically follows a puncture wound by a rusty nail but can follow skin trauma by any object contaminated with spores. C. tetani spores which are commonly found in soil and animal feces are deposited in the wound and can germinate as long as there is a localized environment.
Tetany occurs after the tetanus toxin is taken up at the neuromuscular junction (end plate) and is transported to the central nervous system. There the toxin acts on the inhibitory Renshaw cell interneurons, preventing the release of GABA and glycine, which are inhibitory neurotransmitters. The inhibition of the inhibitory interneurons allows motor neurons to send a high frequency of impulses to muscle cells, which results in a sustained tetanic contraction.
Clinically, the patient with tetanus presents with severe muscle spasms, especially in the muscles of the jaw (called trismus, or lockjaw). The affected patient exhibits a grotesque grinning expression, called risus sardonicus, which is due to spasm of the facial muscles. Mortality is high once the stage of the lockjaw has been reached.
And here's a pic of a guy with the disease:
caep.ca/CMS/images/cjem/p48fig1.jpg
