Duct tape.
Yeah, let's for a second forget the fact that Deadpool got 9 tranquilizer darts re-directed into his face by Cable, before they could use the duct tape.
Or that he handled Captain America, Goliath, Hercules, Falcon and Daredevil (Iron Fist) by himself. Ok, he probably would've lost in the long run, but fact is that he was still standing when Cable showed up.
They dont have to care how hard they hit him and they can just tie up his temporarilly flatlined body.