That's a good question! I guess I'd start with taking down the wallpaper, maybe prime the room and go with earthy, close to neutral tones for the walls. If my assumption is correct and those are windows, I might recommend starting over with the trim entirely. Home Depot has some pretty sweet patterns of trim, but if you're going to have the main focus of the room be the wall, I'd go with something a little more agreeable, something with little-to-no etchings or patterns at all, and just sand those down, hit 'em with some primer, and splash a nice complimentary color on them. Once again, don't make the window trim more eye-catching than the wall color, which should, itself, be pretty neutral.
And if you're worried about sunlight damaging your centerpiece there, you might want to consider perhaps something akin to "blinders" along the sides of your piece, I'd say probably at least half the length of the width of a Silver Age comic book (standard SA comic width being 7 & 1/8th inch wide). Or, if you're really not interested in going crazy with the buzz saw, I'd get a new fixture for some new curtains (complimentary colors in relation to your trim and walls) and maybe just get a cheap set of blinds, which will do the same job of protecting your eye-catching, conversation-inducing investment.
I guess that's what I'd do. Oh. Did you mean what do we think of the comics? 'Cause those are freaking awesome.