I guess the question to ask yourself is - why that exact style? So many people draw anime that you have to do something different in order to get noticed. I don't really see how a journey/quest story would only point to an anime style. You could take just certain aspects of anime and put your own spin on it.
I just read "Understanding Comics" by Scott McCloud (great book, btw) and he mentions several things in Japanese comics that are different from American comics that don't have to do with the way people are drawn. For one, Japanese artists aren't always focused on the action - they like to set up the mood using several panels of seemingly-unrelated events in one location. That's basically unheard of in American comics since the focus is on getting from point A in the story to point B. The way that Japanese comics do action is also different - they blur the environment, keeping the focus on the character, instead of drawing motion lines on the character itself. That puts the audience into the characters' shoes.
It isn't just for looks' sake, there's a point to it all and how you approach the art tells a lot about how you feel about the story, and how you want the audience to feel about it.
