The character of Fu Manchu became a stereotype often associated with the Yellow Peril. Fu Manchu has inspired numerous other characters, and is the model for most villains in later "Yellow Peril" thrillers.[4] Examples include Pao Tcheou, Dr. Azimn, Ancient Wu from True Crime: Streets of LA, Ming the Merciless from Flash Gordon, Li Chang Yen from The Big Four, James Bond adversary Dr. No, Dr Benton Quest's archenemy Doctor Zin from the Jonny Quest television series, Dr. Yen-Lo from The Manchurian Candidate, Lo-Pan from Big Trouble in Little China, Marvel comics foes the Mandarin and the Yellow Claw,DC Comics' Rā's al Ghūl, and Wo Fat from the CBS tv series Hawaii Five-O.
While not of Chinese descent, "Egyptian" arch-villain "Kathulos" (then revealed to be a survived Atlantean) of Robert E. Howard's Skull-Face novella is blatantly inspired by Fu-Manchu.
"Comrade Li" in Peter George's "Commander-1" (1965) is essentially the same type of villain - despite his name having only a thin veneer of Communism or Marxism, being rather a suave philosopher steeped in ancient Chinese learning whose cold-blooded machinations bring about a nuclear holocaust in which nearly all humanity perishes (including China, which he sought to make great) and who eventually meets a suitable gruesome and ignominious end.
Fu Manchu is also one of the earliest known examples of a supervillain, with Professor Moriarty being among the few other precedents.