That changes all the time. Right now: Tom Waits' "Ruby Arms" and Dire Straits "On Every Street." It's not the subject matter but the feeling evoked by the songs. The soldier leaving his lover in the first who is not used to wearing his heart on his sleeve, and the man searching for a woman he is sure must be somewhere out there but always remains just out of reach. The woman in each song can be any ideal or bliss you're forced to turn away from or constantly pursue.
Another song is David Bowie's "Look Back in Anger," one of my all-time favorites. With his usual genius, Bowie sings about looking back at the creative force he used to be and wonders if he can retain that creativity without his younger self's madness.