Hmm, while a strictly CGI feature could potentially be cool, I would personally prefer another live action/animation hybrid. I had an idea for a film, which would be played something like a mix between Back in Action and Roger Rabbit.
Basically an old black and white "wacky/bad" cartoon character (like a Professor something or other for instance), that is bitter about being forgotten after the transition to colour and in particular, the popularity of Bugs Bunny, kidnaps Bugs and a couple of the other "good" characters (Road Runner, Tweety and Porky). Daffy, who is 'filming' Duck Dodgers manages to escape capture. The black and white cartoon would also frame the grandson of Bugs' original animator, who himself happens to be an animator at Warners.
With several characters including the main star gone, cartoons are put on hold and Toon Town put in lock down. Loosing profits, the Warner Brothers (4 human brothers) tell Daffy he must assemble a team to venture into the Warner Vaults to bring Bugs and co. back. So it would be up to Daffy, Wyle E, Elmer Fudd, Sylvester and Foghorn (you know, the actual funny ones), with the help of the animator who was framed, to save the day.