Highly unlikely in all likelihood is what I'd answer. Despite that Loeb didn't rule it out, there really feels to be a separation across the Marvel properties from film to TV to Netflix that goes beyond just a few name drops, wink-wink, nudge-judge moments and of course the legal stuff (contracts being a biggie). Honestly, take out a few of the name drops that Netflix provides to ensure people they're 'connected' and you'd have people thinking it's its own thing, which I do feel it actually is. I feel it's really telling on who makes it to film, who makes it to TV and who makes it to Netflix and the only way I can be convinced they could realistically cross over is if someone from the films (i.e. Hawkeye, Widow, etc.) comes to a smaller screen.
Spider-Man is made for Netflix. Maybe not so much in budget but certainly in his plethora of supporting cast, villains, and story arcs that require more than just a 2/2 and a half hour film that get released every few years between each. Not just Spidey, either. Plenty of superheroes would work better in an episodic format if the budget was there, which is sadly the only thing holding 'em back.
Many people turn to TV now with great, gripping stories like Breaking Bad, Walking Dead, etc. or even superhero properties like Arrow, The Flash, Supergirl (which I still think will slowly lead the way for a new Superman TV series), etc.
In a perfect world, yes absolutely The Defenders would be with Spidey or vice-versa but in this world? Not too sure.
