I'd be up for this. He moved to another city at the end of the series anyway.
They can just say that Martin Crane has died now, which would be the case anyway.
It looks like it would have a new cast, which would really be the only way to keep it fresh as he builds a new life somewhere else.
They could have David Hyde Pierce, Jane Leeves and Peri Gilpin guest start occasionally.
I don't know how well it would be received though, because part of what made the original successful was the interplay between Frasier and Niles.
Which city would they even pick? It would have to be somewhere that hasn't been overdone. Where did he move to at the end? What happened to Ros? I know Daphne and Niles had a baby.