Actually they mentioned some of these in various 'realistic' SPB books over the years like Powers, Rising Stars and others.
Super Strength - Depending on how much you have you could be destroying everything unless you gave it but the merest touch unless you have amazing muscular control. Even if you did, a muscle spasm could kill a person if you shook their hand.
Super Senses - Anything you do could be incredibly painful depending on how sensitive they are. If all your senses are amplified so you could hear someone yelling for help a mile away then living in any city would be a constant nightmare as you'd constantly hear people breathing fifty feet away, you'd feel the sun beating down on your skin like a fire and your clothing would be scraping on your skin. You'd smell the body odours of everyone all around you no matter how clean they were and if you could see that well then you'd be able to see how gross we look at a microscopic level with the bacteria and dead skin flakes and oils coming out from us all the time.
Immortality/extended life - Everyone you know would eventually die. People you love and watched grow from children would age in front of your eyes and die off. Eventually you'd be so used to your own life that people would seem to just grow old in a few years instead of decades due to your own existence dwarfing theirs and you'd eventually lose all touch you humanity unless you made a constant focus to try and integrate yourself in peoples lives on a day by day basis. Eventually should you live long enough, you may be left behind by Humanity as they evolve beyond you or they wipe themselves out with war or disease leaving you alone forever.
Rapid Healing - Continuing from the extended life, you would heal but it would still hurt and you would still bear the psychic scars from things like that. It's one of the reason Wolverine acts like he does (or so it's been guessed at) he has PTSD from the constant pain and torture he puts his body through. He is always twitching for a fight, in a near constant state of alert and anger and looking for enemies around every corner.
Psychic Powers (all types) - Telepathy - Constantly being able to hear peoples thoughts could make you crazy after a while even if you had a constant control over it due to your control slipping and hearing voices murmuring in your sleep. Could be worse if you 'heard' them more when people were angry and you lived anywhere near angry people as you'd constantly hear them screaming in your mind.
Precognition - Seeing the future constantly could drive you insane if you had no control over it. Depending on how it manifested, in your dreams or waking hours it could be even worse. If you saw visions when you were awake you might zone out until they finished. If you had no warning of when they happened then you would never be able to drive a car since you may wind up killing people if you zoned out at the wrong time. If you saw them during your dreaming then you may just drive yourself crazy thinking that you see the future when it's just a dream or think it's just a dream when it's supposed to be a warning from the future.
Telekinesis - Without fine control you may just lose control one day and destroy everything you own because you stubbed your toe or should you be powerful enough then you could destroy and entire building, killing dozens. Even if you did have control but not much practice then you might kill someone by imagining them being strangled and accidentally doing it.
Flight - Not too much bad about that as long as you could control it and knew your limits with height/oxygen limits. If you couldn't control it though, you might just shoot off into space and die unless you were attached to the ground by weights or something.
Super Genius - You're literally smarter than everyone else on the planet and everyone wants you to fix something, world hunger, world peace, diseases, pollution, ect. You may be smarter than everyone but you may not have the knowledge to put things into effect, you may have a reasonable idea of how to fix things but without knowledge of the politics of a certain area or the background in a certain science all your work could be for nothing so you would need to know everything about everything to even start and everyone would still be badgering you for everything else. Even if you could get everything together in a neat and simple package for the entire world to work together on you're still forgetting one thing, PEOPLE ARE IDIOTS! No matter how easy and simple it is, people will still screw it up due to greed, stupidity or just generally being useless.
