My theater was about one third full, some families with younger kids (maybe not the best idea).
The crowd responded to the risqué humor, there was some applause at the end.
I found the tone, coupled with the Animated Series visuals, a little jarring. But I would say that the hit-to-miss ratio on the humor falls mostly the film's favor.
I expect this to be divisive, and Bruce Timm may get some grief again.
Before you watch, maybe ask yourself this question- How do you feel about Harley and Ivy boob-punching each other?
If that sounds appalling, don't see 'Batman and Harley Quinn'. If you think it might be kinda funny, give it a go.