Okay, I see a lot of people didn't understand the last page of the issue. I think I actually understood it pretty easilly.
So Uncle Ben from another dimention was all down in the dumps about Jarvis and May, and he came across the mysterious hobo. Mr. Hobo gave Ben a gun and said "this will help you with your problems". Ben said he didn't think he could ever have that in him to do such a thing. Hobo explained that every time a big decision is made, an alternate universe splits off where whatever decision was made, the opposite decision was made in the new universe.
For example, in 616 Uncle Ben died. This created an alternate universe where Uncle Ben lived...which is where the Ben in our story came from.
Okay, so now we jump to the last couple pages and we see Ben looking all down in the dumps, and Spidey 2011 appears and tells Ben that it's not all over for him, that he's meant for great things, and that one person can change so much. While Spidey 2011 was meaning that Ben shouldn't give up on life because he has a lot to live for still, Ben took that as Spidey assuring him that Ben DOES have it in him to do what "needs" to be done, and that he's MEANT to do it.
Ben shoots Spidey 2011, and thanks him for his words of encouragement.
Now remember the little hobo from the alley? Well, turns out that he was yet another Uncle Ben from yet another alternate universe. Aaaand, since the one Uncle Ben LIVED, the other one did the opposite and died.
That's what I got from it anyway...