Franchises you've been with since the beginning.

[zeptron]

Mario
Sonic
Arkham Series
Original Spyro Trilogy
Kirby
Super Smash Bros
Mortal Kombat
Max Payne

 

[Union Jack]

sonic the hedgehog (play them all except lost world)..the best one being generations in modern times and sonic 2 in old school.

streetfighter
mortal kombat
call of duty
uncharted (my personal favourite modern games!)

 

[Storm22]

Infamous
Uncharted
Mass Effect
Batman Arkham

 

[SpideyVille]

Assassin's Creed
Batman Arkham
Infamous
Uncharted
Splinter Cell (Unable to play Conviction since I own a PS3)
WWE Smackdown/SvR/2K

 

[MessiahDecoy123]

Mario Kart for life!

 

[CJ]

Sonic.

I saw the Sonic 1 display at Toys R Us in 1991 and it began a lifelong obsession.

 

[ChrisBaleBatman]

Metal Gear/ Metal Gear Solid (I was just a kid, and barely remember playing it but my parents had bought and owned the NES, "feel asleep" North American version, and I finally got a Playstation when MGS1 came out.)

Assassin's Creed.

Splinter Cell.

Batman Arkham.

Infamous.

Uncharted.

Mass Effect.

 

[Godzilla2000]

Sonic

 

[Victarion]

Jak and Daxter
Spyro
The Last of Us (?)

 

[Bruce Banner]

Max Payne

Silent Hill

Red Dead

Resident Evil

Twisted Metal

 

[amazingfantasy15]

Super Mario
Metroid
Legend of Zelda
Punch Out
These are the big ones for me, I've owned every console release for the games, for Zelda and Metroid I had all the handheld up until DS as well. These franchises will eventually lead me to buy a WiiU.

More recent franchises are;
Splinter Cell (really Tom Clancy in general for this gen, have everything except HAWX 2)
Assassin's Creed (although I haven't finished 3 yet and haven't started 4, but I do own both games)
Gears of War
Batman Arkham
Bioshock

 

[Sundancer]

Max Payne

Silent Hill

This. Plus I'd be totally into another Marvel: Ultimate Alliance.

 

[Hotwire]

Pretty much any game series that got it's start on the original Nintendo.

Surprised no one mentioned Castlevania.

 

[Spidey-Bat]

How has no one said Pokemon yet? I was 8-9 when it came out and I got sucked into the craze. I've played at least two games per generation.

Can't really think of other franchises. I got into games after a lot of my favorites already started and some of the recent ones I've lost interest with later titles like Uncharted and Assassin's Creed.

 

[GENERAL RAAM582]

Gears of War
Assassin's Creed
Arkham
Infamous
Uncharted (played the first one a year after release)

I can't really think of any other major franchises.