It would be cool to introduce Blade in the Midnight Sons movie. Put him in an ensemble of supernatural heroes for his introduction into the MCU, and give Blade a layered history so he's been doing this for years under the radar of most people. He should already be feared among the world's vampires; a "Boogie-Man" type. I want Blade to have already tussled with Dracula, Deacon Frost, Morbius and other notable vampires in the past. After that, spin Blade off into his solo film with him leading the Nightstalkers. Then he should be used in both franchises moving forward.
I would also have Blade grow up in London like the comics. He is found as a child and saved from murderous vampires by Jamal Afari, his mentor figure predating Whistler (a 1998 Goyer creation for the movie). Jamal takes Eric Brooks to New York where he trains him in slaying Vampires, molding him into the man known as Blade. Its there that Blade eventually loses his accent, being in America for so many years since boyhood and aging considerably slower than humans. Not to mention that Blade would have learned many languages and tongues while being under Jamal Afari's tutelage. That's the first solo film right there. Blade having flashbacks to his earlier training days with Jamal, and alternating between those scenes and the present-day with Blade leading the Nightstalkers.
Shamier Anderson of
Wynonna Earp is my pick.
I think Blade's concept is his constant conflict between his human and vampire sides. And his advantage lies in having all of the strengths of both the species with none of the weaknesses. For me, you wanting to remove the Daywalker aspect equates to removing "Wall-Crawler" from Spider-Man. Sounds like you're describing Hannibal King or even Morbius.