Basically, which form of media did the respective characters more justice. Since, there have been various animated programs devoted to a particular Marvel character, I don't want to turn this into a "which TV program was better" debate. I would like to keep things focused on the individual shows when compared to their live-action counterparts:
Live-action Spider-Man (Sam Raimi/Tobey Maguire) films vs. The Spectacular Spider-Man
Live-action Spider-Man (Sam Raimi/Tobey Maguire) films vs. Spider-Man: The Animated Series (1994)
Live-action Spider-Man (Sam Raimi/Tobey Maguire) films vs. 1967 and 1981 (solo) Spider-Man cartoons respectively
I'm not going to include Spider-Man Unlimited since that wasn't exactly centered on the mainstream comic book continuity. I also don't want to go into the MTV Spidey show since that one was loosely related to the live-action film continuity.
Live-action X-Men films vs. Wolverine and the X-Men
Live-action X-Men films vs. X-Men Evolution
Live-action X-Men films vs. X-Men: The Animated Series
I'm not including the "Pryde of the X-Men" pilot since we'll never really know how that particular show would've evolved (besides the Komani produced arcade game) beyond that single episode.
Live-action Iron Man film(s) vs. Iron Man: The Animated Series (including Tony Stark and Jim Rhodes/War Machine's guest appearances on the Spider-Man and Incredible Hulk cartoons from that period)
I'm not sure that I want to include Iron Man: Armored Adventures into the discussion since that show is based around a teenage Tony Stark.
Live-action Incredible Hulk films (both Ang Lee and Louis Leterrier's versions) vs. The Incredible Hulk: The Animated Series (1996) and the 1982 Hulk series
I'll include Hulk's various guest appearances on shows like Fantastic Four: World's Greatest Heroes and Wolverine and the X-Men.
Live-action Fantastic Four films (the Tim Story films only - not the ashcan Roger Corman version from 1994) vs. Fantastic Four World's Greatest Heroes, Fantastic Four: The Animated Series, and the 1967 Hanna-Barbara cartoon
I'm not going to even bother talking about the 1978 F4 cartoon with H.E.R.B.I.E. instead of the Human Torch.
Live-action Blade films (with Wesley Snipes) vs. Blade's guest appearances on the 1994 Spider-Man cartoon series
Live-action Daredevil film (with Ben Affleck) vs. DD's guest appearances on the 1990s Spider-Man (this includes their depiction of the Kingpin) and Fantastic Four series
The depiction of the Silver Surfer and Galactics (storm cloud and all)
in Fantastic Four: Rise of the Silver Surfer vs. the Surfer's guest appearances on the various F4 cartoons throughout the years and the Surfer's solo cartoon from 1998
Live-action Ghost Rider film (with Nicholas Cage) vs. GR's guest appearances on the '90s Fantastic Four and Hulk cartoons.
I don't know if I want to bring up the Punisher's guest appearances on the '90s Spider-Man cartoon and compare/contrast them to the live-action movies. For all intensive purposes, the animated version of Frank Castle was the santized, PG version (therefore, he wasn't allowed to do any bloodshed whatsoever).
Live-action Spider-Man (Sam Raimi/Tobey Maguire) films vs. The Spectacular Spider-Man
Live-action Spider-Man (Sam Raimi/Tobey Maguire) films vs. Spider-Man: The Animated Series (1994)
Live-action Spider-Man (Sam Raimi/Tobey Maguire) films vs. 1967 and 1981 (solo) Spider-Man cartoons respectively
I'm not going to include Spider-Man Unlimited since that wasn't exactly centered on the mainstream comic book continuity. I also don't want to go into the MTV Spidey show since that one was loosely related to the live-action film continuity.
Live-action X-Men films vs. Wolverine and the X-Men
Live-action X-Men films vs. X-Men Evolution
Live-action X-Men films vs. X-Men: The Animated Series
I'm not including the "Pryde of the X-Men" pilot since we'll never really know how that particular show would've evolved (besides the Komani produced arcade game) beyond that single episode.
Live-action Iron Man film(s) vs. Iron Man: The Animated Series (including Tony Stark and Jim Rhodes/War Machine's guest appearances on the Spider-Man and Incredible Hulk cartoons from that period)
I'm not sure that I want to include Iron Man: Armored Adventures into the discussion since that show is based around a teenage Tony Stark.
Live-action Incredible Hulk films (both Ang Lee and Louis Leterrier's versions) vs. The Incredible Hulk: The Animated Series (1996) and the 1982 Hulk series
I'll include Hulk's various guest appearances on shows like Fantastic Four: World's Greatest Heroes and Wolverine and the X-Men.
Live-action Fantastic Four films (the Tim Story films only - not the ashcan Roger Corman version from 1994) vs. Fantastic Four World's Greatest Heroes, Fantastic Four: The Animated Series, and the 1967 Hanna-Barbara cartoon
I'm not going to even bother talking about the 1978 F4 cartoon with H.E.R.B.I.E. instead of the Human Torch.
Live-action Blade films (with Wesley Snipes) vs. Blade's guest appearances on the 1994 Spider-Man cartoon series
Live-action Daredevil film (with Ben Affleck) vs. DD's guest appearances on the 1990s Spider-Man (this includes their depiction of the Kingpin) and Fantastic Four series
The depiction of the Silver Surfer and Galactics (storm cloud and all)
Live-action Ghost Rider film (with Nicholas Cage) vs. GR's guest appearances on the '90s Fantastic Four and Hulk cartoons.
I don't know if I want to bring up the Punisher's guest appearances on the '90s Spider-Man cartoon and compare/contrast them to the live-action movies. For all intensive purposes, the animated version of Frank Castle was the santized, PG version (therefore, he wasn't allowed to do any bloodshed whatsoever).