I too would want to see it become a rated R movie, but one that has fun with the material and has some humor (but no facebook or internet jokes).
The special effects have to be done with men in suits with animatronic heads. The eyes could be done with CGI.
Design: I would want each turtle to come from a different species. Leonardo would be the one with the most traditional design, but with a more realistic texture and paint.
None of them would have three fingers or two toes. They would have an anatomically correct number of digits.
Donatello would be the heaviest of the group-- something between what is above and the image below.
Michaelangelo would be the most ripped and lean; while Raphael would fall between Leonardo and Donatello in size.
Story: The story would take place ten years from now and explain that a mutagenic serum was used to activate junk DNA in animals to make them humanoid and intelligent. "Master Splinter" was a special agent that was on a mission to retrieve evidence of illegal genetic engineering from the facilities where the serum was being researched. The mission failed and he was caught. They injected him with an anti-serum which turned him into a rat-man. Splinter escapes and grabs four turtles that have been exposed to the serum.
Splinter raised the turtles in the sewers in abandoned tunnels and trained them in the martial arts.
Enemies: The turtles face the foot clan, led by the "Shredder." The turtles find out that Shredder has stolen the ooze that created them and secretly keeps three mutants-- Rocksteady, Bebop, and Usagi (a white rabbit with samurai swords).