I say tie it to the Osborn legacy.
Adrian Toomes would own a company that is taking over the remaining assets from Oscorp, with Harry dead, the majority stock is now open to the public which in turn has allowed Toomes to take control of the company. He is nicknamed, the Vulture, as he picks apart companies financially to make the most profit gain. In dismantling Oscorp, he finds out about the Goblin tech, modifies it to become his flight harness and keeps the green color.
The other Side of Toomes is revealed as he is also running a criminal empire, selling black market weapons to foreign nations. Spider-man gets in his way by preventing a huge weapons trade from going down in the first act.. incidentally, spider-man clues in that the weapons tech is former Oscorp property and looks further to tie it to Toomes.
Toomes is innocent on paper but knowing that Spider-Man could piece things together, he decides to place an underground bounty on his head, Through further research he also finds out that Spider-Man is Peter Parker, as Toomes, he decides to put financial pressure on the Daily Bugle. Picking apart Peter's life in order to finish off the remains.
Too bad it's not a paramount movie, otherwise there could be a SHIELD subplot in there.
Otherwise, I would suggest that Spider-Man receives help from a detective who is also trying to tie Toomes to the weapons shipments by the name of Jean DeWolf
This would culminate in a third act where a spider-man and the vulture engage in an aerial battle at the empire state building where Toomes' plans to assist a terrorist group in destroying it, the result of which causing another 9/11 event, which would put Toomes in a great financial position for selling arms to the American Military and Foreign enemies