This is nitpicking, but I think having Sin born prior to WWII (early to mid 1930s) would probably be a better jumping off point for the character if they would want to use her in Agent Carter. Here's my reasoning:
1) The earlier she's born, the more indoctrination she could have received under the watch of Red Skull. Having Sin as a teenager when Red Skull is jettisoned into the cosmos could also play into her hate for Cap & everyone that stood by him - while teen angst is often overplayed on TV, it's still a real thing in some ways, so taking away her father who has indoctrinated Sin in megalomania & hate could spur the character into a murderous psychopath.
2) I also like the idea of making Sin the arch-nemesis for Peggy. I know it's not canon, but it would tie Peggy's world to Cap's as much as possible (by extension of Cap seemingly killing Red Skull, Sin is driven to kill the one who loved Cap the most). So by having Sin born around 1930, by the time 1950 rolls around it's not a stretch to have a young adult Sin taking it to Peggy in her prime.
I also feel like it's best to steer clear of canon for Sin's character, since the aging process that she goes through in the comics is a little ham-fisted. Just my two cents...