Posted this in another thread but it felt relevant here. There's actually a great deal of connection with the evil illuminiti and Spider-Man though most of it is unknown to the people at the moment.
I know I'm giving bendis far far too much credit before writing this but the dynamic is interesting between these characters once their history is displayed.
I'll start with the hood. I haven't liked what bendis did to him till the NA issue where it shows he's being powered by Dormammu. That's your actual villian for Dark Reign, he would make his move soon enough when all the pieces are assembled.
Osborn is obviously osborn and I'd expect him to do very well as his bag has always been in manipulating others. His main opponent being spider-man who interestingly enough was mystically linked to Doctor Strange as the two that would fight (and have before) Dormammu and Doctor Doom and stop the destruction of the universe.
Doom. Doom would play second fiddle here at first. Think about it. There's this new world order with plenty of potential, Osborn came out on top in SI and the smart move would be to appear subserviant to Osborn till the opportunity for the most gain presents itself. Doom's done this before, he'd do it again. That said he has been a real lackey to Dormammu in the past and when he finds out he's involved that might change his plans directly. Doom also has a conspiracy going with Loki which has not been revealed yet. My guess, Loki and Doom are waiting for their moment, but that would change when they find out who's the real big dog here. He's also linked indirectly to osborn in that both have spider-man as a major component to osborn's countless defeats, and doom's big mystical power play.
Loki, as mentioned, has the plan with doom probably ending with loki in control of asgard and doom in control of earth. Loki is also linked as someone sympathetic to Spider-Man and owing him a favor. What should be really interesting is what happens when he finds out about Dormammu. Dormammu made loki his ***** (rightfully so) and loki needed to team with the avengers to stop him before. Loki hates Dormammu with a passion.
Namor and Emma, I don't know at all. (I know the characters but wtf?)
Again I'm giving too much credit to bendis for even thinking this level of dynamics would play into dark reign, but still wanted to share the interesting though unknown dynamic that ties them.